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Side-effects

Micrograph of fatty liver, as may be seen due to long-term prednisone use. Trichrome stain.

Short-term side-effects, as with all glucocorticoids, include high blood glucose levels, especially in patients with diabetes mellitus or on other medications that increase blood glucose such as tacrolimus) and mineralocorticoid effects such as fluid retention. It is worth noting, however, that the mineralocorticoid effects of prednisone are very minor; this is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly.

Additional short-term side-effects can include insomnia, euphoria and, rarely, mania (in particular, in those suffering from Bipolar disorders I and II). It can also cause depression or depressive symptoms and anxiety in some individuals.^[4] [5]

Long-term side-effects include Cushing's syndrome, truncal weight gain, osteoporosis, glaucoma and cataracts, type II diabetes mellitus, anddepression upon dose reduction or cessation.

[edit]Major

• Increased blood sugar for diabetics
• Difficulty controlling emotion
• Difficulty in maintaining train of thought
• Weight gain
• Facial swelling
• Depression, mania, psychosis, or other psychiatric symptoms
• Unusual fatigue or weakness
• Mental confusion / indecisiveness
• Blurred vision
• Abdominal pain
• Peptic ulcer
• Infections
• Painful hips or shoulders
• Steroid-induced osteoporosis
• Stretch marks
• Osteonecrosis
• Long-term migraines
• Insomnia
• Severe joint pain
• Cataracts or glaucoma
• Anxiety
• Black stool
• Stomach pain or bloating
• Severe swelling
• Mouth sores or dry mouth
• Avascular necrosis
• Hepatic steatosis

[edit]Minor

• Nervousness
• Acne
• Rash
• Increased appetite
• Hyperactivity
• Frequent urination
• Diarrhea
• Removes intestinal flora
• Leg pain/cramps
• Sensitive teeth